SELECT * FROM tbl WHERE col_1 LIKE '%'+col_2+'%'
EDIT:Para MySQL, a sintaxe equivalente seria:
SELECT * FROM tbl WHERE col_1 LIKE CONCAT('%',col_2,'%')
SELECT * FROM tbl WHERE col_1 LIKE '%'+col_2+'%'
SELECT * FROM tbl WHERE col_1 LIKE CONCAT('%',col_2,'%')